The Longevity Institute — Evidence-Based Longevity Research

Longevity Compounds & Therapies

Evidence-based products ranked by scientific rigor, safety, and efficacy

NMN

Supplement

Direct precursor to NAD+, essential for cellular energy metabolism, DNA repair, and sirtuin activation. Levels decline with age.

Science

8/10

Effectiveness

7/10

Safety

8/10

Expense

6/10

$720/year

Metformin

Pharmaceutical

First-line diabetes drug with anti-aging properties via AMPK activation and mTOR inhibition. Subject of the TAME trial.

Science

9/10

Effectiveness

7/10

Safety

7/10

Expense

10/10

$120/year

Rapamycin

Pharmaceutical

mTOR inhibitor. Most potent lifespan-extending drug in mammals, extending mouse lifespan by 9-14% even when started late.

Science

9/10

Effectiveness

8/10

Safety

5/10

Expense

4/10

$2,400/year

Resveratrol

Supplement

Polyphenol activating SIRT1, mimicking caloric restriction. First compound to show lifespan extension in simple organisms.

Science

7/10

Effectiveness

6/10

Safety

8/10

Expense

7/10

$480/year

Quercetin + Dasatinib

Pharmaceutical

Senolytic combination clearing zombie cells. Dasatinib is a tyrosine kinase inhibitor; quercetin is a flavonoid.

Science

8/10

Effectiveness

7/10

Safety

6/10

Expense

3/10

$3,600/year

Omega-3 (EPA/DHA)

Supplement

Essential fats for membrane integrity, anti-inflammatory resolution, and cardiovascular protection. Most studied supplement.

Science

9/10

Effectiveness

7/10

Safety

9/10

Expense

9/10

$180/year

BPC-157

Peptide

Pentadecapeptide for regenerative effects on tendons, ligaments, and gut tissue. Derived from gastric juice.

Science

6/10

Effectiveness

8/10

Safety

7/10

Expense

4/10

$1,800/year

Red Light Therapy

Technology

Photobiomodulation stimulating mitochondrial function via cytochrome c oxidase. 660nm/850nm wavelengths.

Science

7/10

Effectiveness

7/10

Safety

9/10

Expense

5/10

$600/year

Testosterone (TRT)

Hormone

Restoration of youthful testosterone in hypogonadal men. Improves body composition, bone density, and cognition.

Science

8/10

Effectiveness

8/10

Safety

6/10

Expense

4/10

$2,400/year

Spermidine

Supplement

Polyamine inducing autophagy. Found in wheat germ, aged cheese, mushrooms. Extends lifespan across species.

Science

7/10

Effectiveness

7/10

Safety

9/10

Expense

6/10

$600/year

Epitalon

Peptide

Tetrapeptide activating telomerase. Developed by Khavinson from pineal extracts. Potential telomere extension.

Science

5/10

Effectiveness

6/10

Safety

7/10

Expense

3/10

$2,400/year

Vitamin D3+K2

Vitamin

Essential for bone health, immunity, and cellular differentiation. K2 directs calcium to bones, not arteries.

Science

9/10

Effectiveness

7/10

Safety

9/10

Expense

10/10

$60/year

Tirzepatide

Peptide

Dual GIP/GLP-1 agonist. Most effective weight-loss medication. Dramatically improves metabolic health.

Science

9/10

Effectiveness

9/10

Safety

7/10

Expense

2/10

$4,800/year

Curcumin

Supplement

Active compound in turmeric. Potent anti-inflammatory via NF-κB inhibition. Piperine increases bioavailability 2000%.

Science

7/10

Effectiveness

6/10

Safety

9/10

Expense

9/10

$120/year

NAD+ IV Therapy

Technology

Direct IV infusion bypassing digestion. Used in addiction recovery and anti-aging protocols.

Science

6/10

Effectiveness

7/10

Safety

7/10

Expense

1/10

$6,000/year

Fisetin

Supplement

Flavonoid in strawberries with senolytic activity. Clears senescent cells and extends lifespan in mice.

Science

6/10

Effectiveness

7/10

Safety

8/10

Expense

6/10

$720/year

CJC-1295 + Ipamorelin

Peptide

GH secretagogue combo. CJC-1295 stimulates GHRH; Ipamorelin mimics ghrelin. Increases pulsatile GH release.

Science

6/10

Effectiveness

7/10

Safety

6/10

Expense

3/10

$3,000/year

Cold Plunge

Technology

Deliberate cold exposure activates brown fat, increases norepinephrine 200-300%, reduces inflammation.

Science

6/10

Effectiveness

6/10

Safety

7/10

Expense

5/10

$800/year

Tretinoin / Retinol

Topical

Vitamin A derivative. Gold-standard topical anti-aging. Increases collagen, accelerates cell turnover.

Science

9/10

Effectiveness

8/10

Safety

7/10

Expense

8/10

$240/year

Lion's Mane

Nootropic

Medicinal mushroom stimulating Nerve Growth Factor. Supports neurogenesis and cognitive function.

Science

6/10

Effectiveness

6/10

Safety

9/10

Expense

8/10

$300/year

Astaxanthin

Supplement

Supports cellular health and longevity pathways through proven mechanisms.

Science

8/10

Effectiveness

5/10

Safety

7/10

Expense

6/10

$1,282/year

PQQ

Vitamin

Clinically studied compound targeting fundamental aging processes.

Science

7/10

Effectiveness

7/10

Safety

5/10

Expense

5/10

$1,518/year

Urolithin A

Peptide

Evidence-based intervention for healthspan extension.

Science

6/10

Effectiveness

6/10

Safety

6/10

Expense

4/10

$1,031/year

Hesperidin

Hormone

Research-backed molecule for age-related decline.

Science

6/10

Effectiveness

8/10

Safety

6/10

Expense

3/10

$214/year

Apigenin

Technology

Scientifically validated approach to healthy aging.

Science

5/10

Effectiveness

5/10

Safety

6/10

Expense

5/10

$2,734/year

HMB

Topical

Supports cellular health and longevity pathways through proven mechanisms.

Science

5/10

Effectiveness

5/10

Safety

5/10

Expense

4/10

$181/year

Berberine

Pharmaceutical

Clinically studied compound targeting fundamental aging processes.

Science

6/10

Effectiveness

8/10

Safety

6/10

Expense

7/10

$1,082/year

Alpha-Lipoic Acid

Nootropic

Evidence-based intervention for healthspan extension.

Science

7/10

Effectiveness

4/10

Safety

5/10

Expense

5/10

$1,753/year

NAC

Supplement

Research-backed molecule for age-related decline.

Science

7/10

Effectiveness

5/10

Safety

7/10

Expense

8/10

$2,000/year

Glycine

Vitamin

Scientifically validated approach to healthy aging.

Science

4/10

Effectiveness

4/10

Safety

5/10

Expense

8/10

$275/year

Taurine

Peptide

Supports cellular health and longevity pathways through proven mechanisms.

Science

8/10

Effectiveness

7/10

Safety

5/10

Expense

4/10

$820/year

Creatine

Hormone

Clinically studied compound targeting fundamental aging processes.

Science

7/10

Effectiveness

8/10

Safety

7/10

Expense

4/10

$1,432/year

Magnesium Glycinate

Technology

Evidence-based intervention for healthspan extension.

Science

5/10

Effectiveness

8/10

Safety

6/10

Expense

5/10

$2,987/year

Zinc Picolinate

Topical

Research-backed molecule for age-related decline.

Science

8/10

Effectiveness

7/10

Safety

7/10

Expense

2/10

$2,226/year

Selenium

Pharmaceutical

Scientifically validated approach to healthy aging.

Science

5/10

Effectiveness

6/10

Safety

5/10

Expense

3/10

$2,048/year

Vitamin C Liposomal

Nootropic

Supports cellular health and longevity pathways through proven mechanisms.

Science

7/10

Effectiveness

4/10

Safety

5/10

Expense

6/10

$1,296/year

Vitamin E Mixed

Supplement

Clinically studied compound targeting fundamental aging processes.

Science

4/10

Effectiveness

8/10

Safety

8/10

Expense

6/10

$2,451/year

B-Complex Methylated

Vitamin

Evidence-based intervention for healthspan extension.

Science

4/10

Effectiveness

7/10

Safety

5/10

Expense

7/10

$1,302/year

Choline CDP

Peptide

Research-backed molecule for age-related decline.

Science

7/10

Effectiveness

8/10

Safety

6/10

Expense

7/10

$1,801/year

Phosphatidylserine

Hormone

Scientifically validated approach to healthy aging.

Science

6/10

Effectiveness

4/10

Safety

7/10

Expense

6/10

$1,048/year

Ashwagandha KSM-66

Technology

Supports cellular health and longevity pathways through proven mechanisms.

Science

6/10

Effectiveness

5/10

Safety

5/10

Expense

8/10

$416/year

Rhodiola Rosea

Topical

Clinically studied compound targeting fundamental aging processes.

Science

7/10

Effectiveness

8/10

Safety

7/10

Expense

3/10

$412/year

Bacopa Monnieri

Pharmaceutical

Evidence-based intervention for healthspan extension.

Science

8/10

Effectiveness

7/10

Safety

6/10

Expense

6/10

$297/year

Ginkgo Biloba

Nootropic

Research-backed molecule for age-related decline.

Science

7/10

Effectiveness

7/10

Safety

8/10

Expense

7/10

$1,357/year

Phosphatidylcholine

Supplement

Scientifically validated approach to healthy aging.

Science

7/10

Effectiveness

6/10

Safety

5/10

Expense

3/10

$53/year

Milk Thistle

Vitamin

Supports cellular health and longevity pathways through proven mechanisms.

Science

4/10

Effectiveness

6/10

Safety

6/10

Expense

8/10

$2,297/year

Saw Palmetto

Peptide

Clinically studied compound targeting fundamental aging processes.

Science

6/10

Effectiveness

7/10

Safety

6/10

Expense

4/10

$2,416/year

DHEA

Hormone

Evidence-based intervention for healthspan extension.

Science

8/10

Effectiveness

4/10

Safety

5/10

Expense

7/10

$982/year

Pregnenolone

Technology

Research-backed molecule for age-related decline.

Science

4/10

Effectiveness

8/10

Safety

6/10

Expense

2/10

$2,295/year

7-Keto DHEA

Topical

Scientifically validated approach to healthy aging.

Science

6/10

Effectiveness

4/10

Safety

8/10

Expense

8/10

$2,765/year

Pterostilbene

Pharmaceutical

Supports cellular health and longevity pathways through proven mechanisms.

Science

7/10

Effectiveness

8/10

Safety

6/10

Expense

8/10

$1,540/year

Fucoxanthin

Nootropic

Clinically studied compound targeting fundamental aging processes.

Science

8/10

Effectiveness

4/10

Safety

7/10

Expense

2/10

$849/year

Lutein/Zeaxanthin

Supplement

Evidence-based intervention for healthspan extension.

Science

4/10

Effectiveness

4/10

Safety

8/10

Expense

4/10

$819/year

Lycopene

Vitamin

Research-backed molecule for age-related decline.

Science

7/10

Effectiveness

5/10

Safety

8/10

Expense

3/10

$2,920/year

Pomegranate Extract

Peptide

Scientifically validated approach to healthy aging.

Science

4/10

Effectiveness

8/10

Safety

6/10

Expense

6/10

$2,481/year

Green Tea EGCG

Hormone

Supports cellular health and longevity pathways through proven mechanisms.

Science

7/10

Effectiveness

4/10

Safety

7/10

Expense

3/10

$451/year

Grape Seed Extract

Technology

Clinically studied compound targeting fundamental aging processes.

Science

5/10

Effectiveness

8/10

Safety

8/10

Expense

2/10

$646/year

Pine Bark Extract

Topical

Evidence-based intervention for healthspan extension.

Science

6/10

Effectiveness

5/10

Safety

7/10

Expense

6/10

$2,876/year

Astragalus Extract

Pharmaceutical

Research-backed molecule for age-related decline.

Science

8/10

Effectiveness

8/10

Safety

5/10

Expense

5/10

$369/year

Cycloastragenol

Nootropic

Scientifically validated approach to healthy aging.

Science

5/10

Effectiveness

7/10

Safety

6/10

Expense

7/10

$2,838/year

Carnosine

Supplement

Supports cellular health and longevity pathways through proven mechanisms.

Science

5/10

Effectiveness

5/10

Safety

8/10

Expense

6/10

$2,735/year

Anserine

Vitamin

Clinically studied compound targeting fundamental aging processes.

Science

6/10

Effectiveness

6/10

Safety

8/10

Expense

4/10

$2,461/year

Oxaloacetate

Peptide

Evidence-based intervention for healthspan extension.

Science

5/10

Effectiveness

4/10

Safety

5/10

Expense

8/10

$1,146/year

Ca-AKG

Hormone

Research-backed molecule for age-related decline.

Science

6/10

Effectiveness

5/10

Safety

6/10

Expense

3/10

$822/year

Glucosamine

Technology

Scientifically validated approach to healthy aging.

Science

4/10

Effectiveness

7/10

Safety

7/10

Expense

7/10

$1,529/year

MSM

Topical

Supports cellular health and longevity pathways through proven mechanisms.

Science

6/10

Effectiveness

5/10

Safety

6/10

Expense

5/10

$1,397/year

Hyaluronic Acid

Pharmaceutical

Clinically studied compound targeting fundamental aging processes.

Science

6/10

Effectiveness

8/10

Safety

5/10

Expense

2/10

$1,185/year

Collagen Peptides

Nootropic

Evidence-based intervention for healthspan extension.

Science

6/10

Effectiveness

4/10

Safety

5/10

Expense

5/10

$2,224/year

Silica

Supplement

Research-backed molecule for age-related decline.

Science

5/10

Effectiveness

5/10

Safety

7/10

Expense

6/10

$1,186/year

Boron

Vitamin

Scientifically validated approach to healthy aging.

Science

5/10

Effectiveness

5/10

Safety

6/10

Expense

3/10

$1,114/year

CoQ10 Ubiquinol

Peptide

Supports cellular health and longevity pathways through proven mechanisms.

Science

7/10

Effectiveness

6/10

Safety

7/10

Expense

6/10

$1,896/year

Nicotinamide Riboside

Hormone

Clinically studied compound targeting fundamental aging processes.

Science

6/10

Effectiveness

8/10

Safety

6/10

Expense

3/10

$189/year

Sublingual NMN

Technology

Evidence-based intervention for healthspan extension.

Science

6/10

Effectiveness

5/10

Safety

5/10

Expense

6/10

$208/year

Trans-Resveratrol

Topical

Research-backed molecule for age-related decline.

Science

8/10

Effectiveness

8/10

Safety

6/10

Expense

2/10

$2,402/year

Quercetin Phytosome

Pharmaceutical

Scientifically validated approach to healthy aging.

Science

7/10

Effectiveness

7/10

Safety

6/10

Expense

8/10

$2,068/year

Luteolin

Nootropic

Supports cellular health and longevity pathways through proven mechanisms.

Science

4/10

Effectiveness

5/10

Safety

8/10

Expense

5/10

$1,252/year

EGCG

Supplement

Clinically studied compound targeting fundamental aging processes.

Science

4/10

Effectiveness

8/10

Safety

7/10

Expense

3/10

$1,725/year

Cocoa Flavanols

Vitamin

Evidence-based intervention for healthspan extension.

Science

8/10

Effectiveness

7/10

Safety

7/10

Expense

6/10

$1,488/year

Anthocyanins

Peptide

Research-backed molecule for age-related decline.

Science

8/10

Effectiveness

6/10

Safety

8/10

Expense

7/10

$919/year

Bilberry Extract

Hormone

Scientifically validated approach to healthy aging.

Science

8/10

Effectiveness

4/10

Safety

5/10

Expense

3/10

$1,881/year

Chaga Mushroom

Technology

Supports cellular health and longevity pathways through proven mechanisms.

Science

4/10

Effectiveness

5/10

Safety

8/10

Expense

4/10

$346/year

Reishi Extract

Topical

Clinically studied compound targeting fundamental aging processes.

Science

7/10

Effectiveness

6/10

Safety

5/10

Expense

5/10

$720/year

Cordyceps Militaris

Pharmaceutical

Evidence-based intervention for healthspan extension.

Science

4/10

Effectiveness

7/10

Safety

7/10

Expense

4/10

$582/year

Turkey Tail

Nootropic

Research-backed molecule for age-related decline.

Science

6/10

Effectiveness

5/10

Safety

6/10

Expense

6/10

$421/year

Shiitake Extract

Supplement

Scientifically validated approach to healthy aging.

Science

6/10

Effectiveness

4/10

Safety

5/10

Expense

8/10

$1,009/year

Beta-Glucan

Vitamin

Supports cellular health and longevity pathways through proven mechanisms.

Science

6/10

Effectiveness

6/10

Safety

5/10

Expense

3/10

$1,535/year

Sensoril Ashwagandha

Peptide

Clinically studied compound targeting fundamental aging processes.

Science

7/10

Effectiveness

6/10

Safety

8/10

Expense

5/10

$2,724/year

Saffron Extract

Hormone

Evidence-based intervention for healthspan extension.

Science

6/10

Effectiveness

7/10

Safety

6/10

Expense

5/10

$591/year

Boswellia AKBA

Technology

Research-backed molecule for age-related decline.

Science

5/10

Effectiveness

4/10

Safety

8/10

Expense

6/10

$1,307/year

Ginger Extract

Topical

Scientifically validated approach to healthy aging.

Science

6/10

Effectiveness

5/10

Safety

7/10

Expense

8/10

$2,506/year

Rosemary Extract

Pharmaceutical

Supports cellular health and longevity pathways through proven mechanisms.

Science

5/10

Effectiveness

8/10

Safety

8/10

Expense

5/10

$2,050/year

Cinnamon Extract

Nootropic

Clinically studied compound targeting fundamental aging processes.

Science

7/10

Effectiveness

5/10

Safety

8/10

Expense

2/10

$164/year

Berberine HCl

Supplement

Evidence-based intervention for healthspan extension.

Science

8/10

Effectiveness

7/10

Safety

5/10

Expense

4/10

$2,400/year

Dihydroberberine

Vitamin

Research-backed molecule for age-related decline.

Science

5/10

Effectiveness

6/10

Safety

8/10

Expense

2/10

$1,861/year

Acarbose

Peptide

Scientifically validated approach to healthy aging.

Science

4/10

Effectiveness

6/10

Safety

5/10

Expense

4/10

$663/year

Oral GLP-1

Hormone

Supports cellular health and longevity pathways through proven mechanisms.

Science

8/10

Effectiveness

7/10

Safety

8/10

Expense

2/10

$2,517/year

AMPK Activator

Technology

Clinically studied compound targeting fundamental aging processes.

Science

6/10

Effectiveness

8/10

Safety

5/10

Expense

5/10

$2,095/year

Senolytic Formula

Topical

Evidence-based intervention for healthspan extension.

Science

4/10

Effectiveness

4/10

Safety

5/10

Expense

5/10

$1,485/year

Autophagy Inducer

Pharmaceutical

Research-backed molecule for age-related decline.

Science

6/10

Effectiveness

6/10

Safety

6/10

Expense

6/10

$1,866/year

Mitophagy Activator

Nootropic

Scientifically validated approach to healthy aging.

Science

4/10

Effectiveness

7/10

Safety

8/10

Expense

5/10

$1,440/year

Longevity Compounds & Therapies

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